Factors in early life programming of reproductive fitness

Title: Factors in early life programming of reproductive fitness
Creator: Sominsky, L.; Fuller, E. A.; Hodgson, D. M.
Relation: Neuroendocrinology Vol. 102, Issue 3
Publisher Link: http://dx.doi.org/10.1159/000431378
Publisher: S. Karger AG
Resource Type: journal article
Date: 2015
Description: Fertility rates have been declining worldwide, with a growing number of young women suffering from infertility. Infectious and inflammatory diseases are important causes of infertility, and recent evidence points to the critical role of the early-life microbial environment in developmental programming of adult reproductive fitness. Our laboratory and others have demonstrated that acute exposure to an immunological challenge early in life has a profound and prolonged impact on male and female reproductive development. This review presents evidence that perinatal exposure to immunological challenge by a bacterial endotoxin, lipopolysaccharide, acts at all levels of the hypothalamic-pituitary-gonadal axis, resulting in long-lasting changes in reproductive function, suggesting that disposition to infertility may begin early in life.
Subject: perinatal programming; inflammation; lipopolysaccharide; reproductive development
Identifier: http://hdl.handle.net/1959.13/1342061
Identifier: uon:28879
Identifier: ISSN:0028-3835
Language: eng
Reviewed

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